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Clark Level and Breslow Thickness for Melanoma Staging
You wonder what foreign language she's speaking—indeed, melanoma jargon can be confusing and exasperating. To help you understand why a particular treatment was chosen for you, here is a brief explanation of what these terms mean. If your reggae roots volume 21 sees a suspicious mole during a skin exam, the next step is a skin biopsy.
If the biopsy reveals a melanoma, the pathologist will examine the biopsy to determine the stage extent s melanoma je sladje google the disease in order to effectively plan your treatment. First reported by Alexander Breslow, MD, inthe Breslow thickness is defined as the total vertical height of the melanoma, from the very top called the "granular layer" to the area of deepest penetration in the skin.
An instrument called an "ocular micrometer" is used to measure the thickness of the excised removed tumor. In general, the higher the Breslow thickness, the worse the prognosis—in other words, the thicker the melanoma, the greater chance it has of spreading. Here are 5-year survival rates based on a certain Breslow thickness.
Keep in mind that these survival rates are averages and may not reflect your individual case:. Due to its accuracy in predicting outcomes, the Breslow thickness has been incorporated into the standard TNM staging system for melanoma. The Clark level refers to how deep the tumor has penetrated into the layers of the skin.
This system was originally developed by W. Clark, MD, back in Clark levels are officially defined as follows:. This all being said, Clark's levels are rarely used for calculating prognosis now. This is because research has shown them to be less predictive of outcome, less reproducible, and more subjective than the Breslow depth. Other disadvantages of this staging system are that it is often very difficult to differentiate between Clark Level II and Level III, and it can't be used on melanomas of the palms and soles.
Even then, it is only used as a default if the mitotic rate of the thin melanoma cannot be determined. The mitotic rate refers to the number of cancer cells that are dividing. A higher mitotic rate indicates that the cancer is more likely to spread.
Try not to get too bogged down in the details of the melanoma staging process. Instead, focus on what s melanoma je sladje google stage of your cancer means for your treatment and outlook. S melanoma je sladje google up for our Health Tip of the Day newsletter, and receive daily tips that will help you reach your goals. There was an error. Please try again. Thank you,for signing up. American Cancer Society. May Melanoma skin cancer stages. Survival rates for melanoma skin cancer, by stage.
Final version of AJCC melanoma staging and classification. J Clin Oncol. More in Skin S melanoma je sladje google. Here is how to interpret them. Keep in mind that these survival rates are averages and may not reflect your individual case: Clark levels are officially defined as follows: Level I: Confined to the epidermis topmost layer of skin called "in situ" melanoma Level II: Invasion of the papillary upper dermis Level III: Filling of the papillary dermisbut no extension into the reticular lower dermis Level IV: Invasion of the reticular dermis Level V: Invasion of the deep, subcutaneous tissue.
Was this page helpful? Thanks for your feedback! Email Address Sign Up There was an error. What are your concerns? Article Sources American Cancer Society. Prognostic s melanoma je sladje google analysis of 17, melanoma patients: Continue Reading. Article Diagnosing Skin Cancer.
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